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Research

The Grenoble group belongs to the Institute of Structural Biology (IBS). The expertise of the Group is related to protein engineering, overexpression and purification, functional (molecular interactions analysis) and structural studies (X-Ray, NMR or MS). Three proteins systems related to immunity are studied in the Fieschi's Group: NADPH Oxidase (involved in Chronic Granulomatous Disease (CGD)), HIV co-receptors (CCR5 and CXCR4), and C-type lectins (DC-SIGN and Langerin). The Grenoble group uses the DC-SIGN production and manipulation for molecular interaction studies, but also to similar expertise with langerin, another lectin related to this network.

The group has available all equipment for bacterial manipulation, and culture as well as for molecular biology (DNA manipulation, cloning, mutagenesis…). Moreover, they are equipped with three FPLC station and a wide set of chromatographic support for protein purification as well as all the classical equipment needed for protein biochemistry.Apart from the equipment specific from the group, IBS is organized as a series of technical platforms.